Scientist Cell Culture Engineering

Profile

Bristol-Myers Squibb is a global Biopharma company committed to a single mission: to discover, develop, and deliver innovative medicines focused on helping millions of patients around the world in disease areas such as oncology, cardiovascular, immunoscience and fibrosis.

Join us and make a difference. We hire the best people and provide them with a work environment that places a premium on diversity, integrity, collaboration and personal development. Through a culture of inclusion, we create a better, more productive work environment. We believe that the diverse experiences and perspectives of all our employees help to drive innovation and transformative business results.

Job Description:

Bristol-Myers Squibb is a global Biopharma company committed to a single mission: to discover, develop, and deliver innovative medicines focused on helping millions of patients around the world in disease areas such as oncology, cardiovascular, immunoscience and fibrosis.

Join us and make a difference. We hire the best people and provide them with a work environment that places a premium on diversity, integrity, collaboration and personal development. Through a culture of inclusion, we create a better, more productive work environment. We believe that the diverse experiences and perspectives of all our employees help to drive innovation and transformative business results.

CAR-T cell therapies are a revolutionary advance in medical treatment, but the success of these new treatments depends upon our ability to develop strong underlying science to inform process development. As part of the pipeline process platform and technology team, we are seeking a highly capable and independent Scientist to work with a multidisciplinary group to support innovative projects, which aim to improve the understanding of in vitro cell culture conditions on cell therapy manufacturing performance and product attributes. The candidate will be supporting multiple pipeline programs (i.e. gene edited autologous and allogenic cell therapies as well as viral vector upstream process) by executing experiments with a combination of scale-down models and manufacturing scale technologies and equipment. He/she will be responsible for new technology evaluation, development, and application for process improvement. This position is a hands-on, laboratory-based role.

The successful candidate will:

Design and execute experiments to assess impact of cellular metabolism and cytokine signaling on cell phenotype and functionality of gene edited cell therapies

Optimize cell culture conditions as well as media components that can help improve process performance and achieve desired product attributes

Investigate the root causes for process variations and develop appropriate control strategies to improve cell culture process consistency

Understand and apply engineering principles of bioreactor optimization and operation in cell therapy and viral vector manufacturing process

Collaborate with Product Sciences to investigate the relationships between cell attributes and cell culture conditions

Author reports detailing experimental work and summarizing results

Maintain a safe work environment in accordance with policies/procedures/regulations

Stay current with the latest trends and findings in the field and present results in scientific conferences

Basic Qualifications:

Ph.D. in Biochemical, Chemical, or Biomedical Engineering with relevant research experience, or B.S with 9 years of relevant industrial experience, or M.S. with 7 years of relevant industrial experience

Proficient in standard cell culture procedures and associated aseptic techniques

Demonstrated independence in experimental design, execution, data analysis and troubleshooting

Demonstrated track record of success and sound technical qualifications and knowledge in cell culture, cell process development, and GMP manufacturing

Deep understanding of cell metabolic or signaling pathways and experience with new technology evaluation with minimal supervision

Familiar with design of experiments (DOE) screening methodology

Multi-parameter flow cytometry and proficiency in FACS data analysis programs

Ability to organize, communicate, and present complex data sets to key stakeholders from diverse backgrounds

Excellent technical writing and oral communication skills

Preferred Qualifications:

Experience with cell separation technologies and FACS sorting

Experience in the characterization, culture, and manipulation of T cells

Deep understanding of key T cell regulatory and differentiation pathways is preferred but not required

Experience designing, executing, and interpreting genomics and transcriptome assays (NGS, RNA-Seq, Single Cell RNA-Seq, AmpliSeq, etc.) is preferred but not required

Driven individual that works well with little supervision and is collaborative in multidisciplinary teams

Bristol-Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees the resources to pursue their goals, both at work and in their personal lives.

Bristol-Myers Squibb is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or protected veteran status.

Company info

Bristol-Myers Squibb Company
Website : http://www.bms.com